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The pan-European Stoxx 600 was up around 0.86 percent shortly after the opening bell, with all sectors and major bourses in positive territory.
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The Nikkei share average ended 0.3 percent lower at 21,148.02, the lowest close since late March.
The broader Topix fell 0.9 percent to 1,575.31, the lowest closing level since May 2017.
Financial shares underperformed, dragged down by a sell-off in global peers such as Citigroup and Bank of America , after uncertainty over Britain’s exit from the European Union kept investors on edge about global growth.
• Chinese shares rose on Tuesday after Beijing confirmed it was still in trade talks with Washington, but investor confidence remained fragile in Asia after Britain’s prime minister postponed a Brexit vote, sending the pound to near 20-month lows.
At the midday break, the Shanghai Composite Index was 0.3 percent higher at 2,591.75.
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