The Nikkei share average slid 1.4 percent to 16,412.21, ending a four-day winning streak. The benchmark index ended the week 1.9 percent higher.
Hong Kong shares fell for a third straight week, with the main index hitting a two-month low on Friday, as worries mount over economic growth in the city and China.
The Hang Seng index fell 1.0 percent, to 19,719.29, recording a weekly loss of 1.9 percent. The China Enterprises Index lost 1.3 percent, to 8,301.39 points.
There are rising concerns that China's pick-up in economic activity is losing steam, amid signs Beijing may not loosen monetary policy to stimulate growth
China stocks closed at their lowest level in two months on Friday, with the benchmark index registering its fourth week of declines, amid increasing concerns that a recent pick-up in economic activity may be fizzling out.
The Shanghai Composite Index .SSEC lost 0.3 percent to 2,827.11 points, its lowest close since March 11. The blue-chip CSI300 index .CSI300 fell 0.5 percent to 3,074.94.
For the week, the SSEC lost 3 percent, and the CSI300 shed 1.8 percent. Both indexes fell for the fourth straight week.
Reference: Reuters