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Japan's Nikkei share average fell on Wednesday as investors locked in profits ahead of a potentially market-disrupting British referendum later this week.

The Nikkei shed 0.6 percent to 16,065.72 after rising 4.7 percent over the past three days.

China's main stock indexes closed up on Wednesday as more investors bet Britain will vote to stay in the European Union this week, while Federal Reserve Chair Janet Yellen's cautious tone on future rate hikes also soothed market sentiment.

The CSI300 index of the largest listed companies in Shanghai and Shenzhen rose 0.9 percent to 3,133.96 points, while the Shanghai Composite Index also gained 0.9 percent to 2,905.55 points.

Hong Kong stocks rose for a fourth straight day on Wednesday as investors were hopeful Britain will vote to stay in the European Union this week, while Federal Reserve Chair Janet Yellen's cautious tone on future rate hikes also soothed sentiment.

The Hang Seng index rose 0.6 percent, to 20,795.12, while the China Enterprises Index gained 0.7 percent, to 8,763.11 points.

Reference: Reuters