Consumer and technology stocks, including Amazon, led gains on Wall Street on Tuesday, while a perceived win by Democrat Hillary Clinton in Monday's first presidential debate gave broader support to equities.
The S&P 500 technology sector rallied 1.15 percent, powered by a 1.85 percent gain in Microsoft and a 1.08 percent rise in Facebook.
The Dow Jones industrial average rose 0.74 percent to end at 18,228.3 points and the S&P 500 gained 0.64 percent to 2,159.93.
Asian stocks were mostly lower on Wednesday, with European banking sector concerns and lower crude oil prices dulling investors' appetite for riskier assets.
Equities in Asia had gained the previous day on a perceived win by Democrat Hillary Clinton at the first presidential debate over Republican Donald Trump, who is seen as creating greater uncertainty for the U.S. and global economies.
MSCI's broadest index of Asia-Pacific shares outside Japan .MIAPJ0000PUS was down 0.1 percent, erasing earlier modest gains.
Reference: Reuters